HSC News December 2, 2004
Media/Communications · HSC Online News
In this issue: December 2, 2004

1. Pick a new News name: A newsletter by any other name.

2. NIH gives USF $1.1 million to improve Alzheimer's disease vaccine.

3. New lab probes breathing problems triggered by the environment.

4. A positive sign.

5. In the News.

6. Combination antibiotic therapy improves Chlamydia-induced arthritis.

7.Cannabis may combat cancer-causing herpes virus .

8..PT class commits to professionalism .

9..Arts and Crafts Show Dec 10 and HSC Holiday Party Dec. 17.

10.Mark your calendars for Mini-Med School.


 

A newsletter by any other name

Things are moving and changing at the Health Sciences Center…but there is at least one constant, namely the spirit of pride in the amazing accomplishments of our faculty, staff, residents and students. This newsletter needs to reflect that excitement and collaboration that defines our colleges of medicine, nursing and public health and our school of physical therapy.

So, here's my offer. In the true spirit of faculty and staff involvement as well as playing to the competitive spirit that I know exists out there, whoever submits the name for the HSC News that we end up using will get a free dinner for two at their favorite Tampa restaurant. Be creative and send your suggestions by Dec. 15 to our editor, Sarah Worth at sworth@hsc.usf.edu.

The winning name will reflect what our HSC communications strive to do, namely bring us closer together in a spirit of collaboration that reflect our finest accomplishments.


The name should also be appropriate for both our hard copy and on-line versions of the newsletter. Our goal, as with everything else we will do, is to bring technology as a resource to bring the different missions and colleges closer together. An integrated news site will allow you to find out what your colleagues are doing and where USF Health Sciences Center is going.

On a daily basis, in my short time here, I have been amazed at the individual and collaborative discoveries, patient care and educational activities that happen at USF. The fact that these activities have occurred despite our diffuse geographic locations is even more impressive. This newsletter and all our communications will serve as a vehicle to help bridge those geographic gaps and build the foundation for an integrated Health Sciences Center within a great University.

President Genshaft has set the course for us…becoming a top 50 public research University. The Health Sciences Center will lead that effort, and others, that will allow us to garner national attention and prestige, making your appointment or diploma that much more valuable.

I intend to take every opportunity to express my pride in the work that you do, and our communications will reflect that goal. A newsletter by any other name…at least until you choose the best one, and have a great dinner on us!

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NIH gives USF $1.1 million to improve Alzheimer's disease vaccine

By Anne DeLotto Baier

USF neuroscientists have been awarded a $1.1 million federal grant to improve the safety and effectiveness of an Alzheimer's vaccine in a mouse model for the disease. Jun Tan, MD, PhD, director of the Neuroimmunology Laboratory in the USF Department of Psychiatry, is principal investigator for the four-year grant from the National Institute for Neurological Disorders and Stroke. The co-principal investigator is David Morgan, PhD, director of the Alzheimer's Disease Research Laboratory in the USF Department of Pharmacology and Therapeutics.

The study builds on previous USF laboratory and animal model studies tracking the role of the brain's immune system in Alzheimer's disease. Under certain circumstances, immune cells in the brain, known as microglia, promote the inflammatory and destructive process that can lead to Alzheimer's disease. The USF researchers demonstrated that once a specific molecule on the surface of microglia, CD40, gets activated by its partner, CD40 ligand, the scene is set for microglial injury to the main cells in the brain – the neurons. They also showed that the trigger for this harmful immune response associated with brain inflammation can be blocked by an antibody.

Drs. Tan and Morgan plan to administer this anti-CD40 ligand antibody to mice genetically engineered to develop symptoms similar to Alzheimer's disease. The mice will also be immunized with an investigational anti-Alzheimer's vaccine shown to remove beta amyloid plaques that accumulate in the brain, thereby leading to nerve damage and memory loss. While the vaccine has shown clear benefit in mice, some Alzheimer's patients participating in clinical trials of the vaccine fell ill with brain inflammation. The researchers hypothesize that the combination treatment may have "super-additive effects" in removing Alzheimer's-associated plaques from the brain, while protecting the brain from the side effect of microglia-induced inflammation.

"This approach shifts the focus from treating symptoms of Alzheimer's disease to treatments that slow down the disease or prevent it altogether," Dr. Tan said.

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New lab proves breathing problems triggered by the environment

By Anne DeLotto Baier

Breathing. It's something we do without thinking – unless it becomes a struggle.

The USF College of Public Health has opened a respiratory laboratory that uses new technology to study breathing problems with little patient discomfort and effort. Researchers are delving into the inner workings of the lungs to investigate whether biochemical changes in lung defenses, as people age, make older populations more susceptible to respiratory tract infections and air pollution.

 Dr. Stuart Brooks (right), director of the USF Breath Lab, measures exhaled breath nitric oxide concentration as Callie Kabrick breathes into an analyzer. Photo by Eric Younghans.
"There are definite changes in the lungs as we age — the tissue becomes less elastic, muscle endurance declines and immune response to foreign microorganisms may decrease," said Stuart Brooks, MD, director of the USF Breath Lab. "No one has really looked at the underlying reasons why older people may be at greater risk for lung injury from environmental exposures. We want to understand these differences so we can identify better ways to prevent and treat the potentially damaging effects of inhaled pollutants and other irritants."

The researchers also plan to study those with asthma and chronic obstructive pulmonary disease in a medically monitored setting. James McCluskey, MD, MPH, assistant professor of occupational medicine, and Thomas Truncale, MD, assistant professor of pulmonary medicine, work with Dr. Brooks in the interdisciplinary breath research lab. Dr. Brooks, a professor of environmental and occupational health, said he expects to draw on the expertise of faculty from medicine, public health, chemistry and engineering. Physicians from USF's occupational medicine residency and a post-doctoral fellow in pulmonary medicine will train in the lab.

The 480-square-feet facility houses more than $200,000 worth of state-of-the-art equipment to noninvasively collect and analyze components of exhaled breath or sputum samples. Initial funding came from the National Institute for Occupational Safety and Health through the National Occupational Research Agenda. A new pulmonary function test allows patients to breath normally into a mouthpiece and uses different sound wave frequencies to measure air flow resistance and determine how well their lungs are working. This oscillimeter replaces the traditional breathing test, spirometry, which requires patients to blow forcefully into a tube for several seconds to register a reading.

By having patients breath into a tube covered by a below-freezing jacket, the researchers can capture very small droplets of condensed breath. The condensation may contain certain indicators of lung injury such as inflammatory chemicals or free radicals — byproducts of cell metabolism that can damage cells and tissue. This technique replaces washing out the lungs with fluid, which requires inserting a bronchoscope or obtaining lung samples by making small snips in the tissue during the bronchoscope examination. An inhalation chamber will help researchers track in real-time the respiratory effects of low concentrations of fly ash, the byproduct of coal-burning power plants. The Plexiglass chamber, designed by USF industrial hygienist Yehia Hammad, ScD, generates and circulates airborne pollutants at concentrations significantly less those currently approved as safe by federal air quality standards. Volunteers who spend time in the chamber will be tested to determine whether inhaling different levels of invisible pollutants subtly impacts the lung's defenses at the molecular level.

Dr. Brooks has obtained approval from the Food and Drug Administration to use capsaicin, the active ingredient in chili pepper, to study cough reflexes in older and younger persons. The researchers will determine if people over age 55 have a weaker cough reflex than adults under age 30. Coughing is a basic way to clear foreign particles from the airway, and if that protective capacity declines harmful secretions may accumulate in the lungs, Dr. Brooks said.

The Breath Lab team will look for evidence of lung membrane injury and inflammation and try to define how pulmonary defense mechanisms, such as the ability to neutralize damaging free radicals, change with age. The findings may have implications for an increasingly older workforce.

"In the next 20 years, workers over age 55 will invariably be performing industrial jobs for longer periods in place of younger workers," Dr. Brooks said. "The question remains are older workers at greater risk for illness from inhaling particulates, gas, vapors or fumes than younger workers?"

Dr. Brooks and his colleagues have applied for grants from the National Institutes of Health and the U.S. Department of Energy to support their innovative research.

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A positive sign




More than 500 folks from HSC picnicked under the oaks on the corner of Holly and Magnolia, the site of the future Center for Advanced Health Care. The new facility will offer clinical services in an environment that has collaboration at its core. The official groundbreaking is set for the spring, but the unveiling of an impressive sign was the high note of Nov. 22 lunch gathering. Dr. Stephen Klasko, vice president for Health Sciences, donned an apron and served fresh onion rings. Hungry staff lined up and ate well. And HSC leaders posed with USF President Judy Genshaft (rigth) in front of the larger-than-life sign. From left is Dr. Sandy Quillen (School of Physical Therapy), Dr. Donna Petersen (College of Public Health), Dr. Klasko (HSC and College of Medicine), Dr. Patricia Burns (College of Nursing), and Genshaft. Photo by Eric Younghans.

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In the News

• The USF College of Medicine was featured in a front-page Oct. 21 Tampa Tribune story on the nationwide influx of women into medical schools. For the first time in the school's history, women are in the majority. Peter Fabri, MD, associate dean and director of USF's residency programs, commented on how the increase in women is impacting graduate medical education. Also quoted were second-year medical student Jennifer Beckman, president of the local chapter of the American Medical Women's Association, and fourth-year student Myra Carreon, who balances medical school and raising a family.

Patricia Gorzka, PhD, ARNP, associate professor and manager of the Nursing Continuing Education Program, was profiled in the Oct. 22 Tampa Bay Business Journal as the winner of the journal's 2004 Health Care Heroes Award in the Health Care Educator category. Health care hero finalists mentioned in the same issue included USF's Thomas Freeman, MD, professor of neurosurgery, Health Care Innovation & Research category; Alexander Rosemurgy, MD, director of general surgery, Physicians; Ronald Schonwetter, MD, professor and director of geriatric medicine, Lifetime Achievement; and Estrellita "Lo" Berry, project director of the federal Central Hillsborough County Healthy Start Project at the Chiles Center, Community Outreach.

• USF vascular surgeon Brad Johnson, MD, commented on a less invasive alternative to carotid endarterectomy, a treatment to reduce risk of stroke, in the Oct. 22 Tampa Bay Business Journal. Dr. Johnson participated in FDA trials for the carotid stents, designed to prop open the carotid artery and ease blood flow to the brain. Dr. Johnson said he expects the new stenting procedure, initially approved only for high-risk patients, to become more widely accepted.

Richard Lockey, MD, professor and director of the Division of Allergy and Immunology, discussed the health effects of indoor mold Oct. 25 on ABC Action News Ch. 28. Dr. Lockey said mold is not as toxic as the public fears and mold allergies rank far behind allergic reactions to dust mites, cockroaches and dog and cat dander.

• USF pediatrician and child health policy expert Lisa Simpson, MB, BCH, MPH, commented for a Nov. 1 American Medical News story on the challenges of translating research into clinical practice. The article cited Dr. Simpson's own struggles to get evidence-based care for her child's ear infections.

By Anne DeLotto Baier
abaier@hsc.usf.edu

Combination antibiotic therapy improves Chlamydia-induced arthritis

By Anne DeLotto Baier

A prolonged regimen of combined antibiotics was significantly more effective than a single antibiotic in treating patients with arthritis triggered by Chlamydia. The clinical trial by USF rheumatologists, published in the October issue of the Journal of Rheumatology, compared patients treated with doxycycline alone to those receiving doxycycline and rifampin.

"This is the first study to demonstrate the benefit of combination antibiotics in treating chronic inflammatory arthritis possibly secondary to persistent Chlamydia," said the study's lead author John Carter, M.D, assistant professor of medicine. If the preliminary findings are proven effective by more extensive studies, Dr. Carter said, combination antibiotics might have applications for the treatment of other conditions linked to persistent Chlamydia, such as hardening of the arteries, pelvic inflammatory disease, asthma and trachoma, the leading cause of preventable blindness.

Chlamydia, a sexually-transmitted or respiratory-acquired bacterial infection, can lead to a painful condition known as reactive arthritis in those genetically susceptible. Using antibiotics to treat reactive arthritis remains controversial — some studies have shown benefit while others have not. However, previous studies investigated treatment with various single antibiotics and typically lasted no longer than three months.

The USF randomized study treated 30 patients with chronic inflammatory arthritis for nine months. Half received 100 mg. doxycycline twice daily, and half received the same prescription of doxycycline along with 600 mg. rifampin daily. A third of the patients reported a possible Chlamydia infection before their arthritis symptoms, and patients whose arthritis may have been triggered by dysentery (inflammation of the intestines) were excluded from the study. Patients treated with the combination doxycycline/rifampin reported significantly less back pain and morning stiffness than patients treated with doxycycline alone. Upon examination, they also had fewer swollen and tender joints. Dr. Carter said the findings were promising, but need further study. His coinvestigators were Joanne Valeriano, MD, and Frank Vasey, MD.

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Cannabis may combat cancer-causing herpes virus

The compound in marijuana that produces a high, delta-9 tetrahydrocannbinol or THC, may block the spread of several forms of cancer causing herpes viruses, USF College of Medicine scientists report.  The findings, published Sept. 15 in the online journal BMC Medicine, could lead to the creation of antiviral drugs based on nonpsychoactive derivatives of THC.

The gamma herpes viruses include Kaposi's Sarcoma Associated Herpes virus, which is associated with an increased risk of cancer that is particularly prevalent in AIDS sufferers. Another is Epstein-Barr virus, which predisposes infected individuals to cancers such as Burkitt's lymphoma and Hodgkin's disease.

Once a person is infected, these viruses can remain dormant for long periods within white blood cells before they burst out and begin replicating. This reactivation of the virus boosts the number of cells infected thereby increasing the chances that the cells will become cancerous.

The USF team, led by virologist Peter Medveczky, MD, found that this sudden reactivation was prevented if infected cells were grown in the presence of THC. Furthermore, the researchers showed that THC acts specifically on gamma herpes viruses. The chemical had no effect on another related virus, herpes simplex-1, which causes cold sores and genital herpes. Dr. Medveczky, a professor in the Department of Medical Microbiology and Immunology, emphasized that more studies are needed. He added that THC has also been shown to suppress the immune system so smoking marijuana could "do more harm than good" to patients whose immune systems are often already weakened.

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PT class commits to professionalism

 

With friends, families and community clinicians in attendance, 29 members of the USF School of Physical Therapy's master's class of 2006 formally accepted the responsibility and obligations of entering the profession in a ceremony Oct. 21. Keynote speaker for the event was Dr. Andrew Guccione, senior vice-president of the American Physical Therapy Association. Each student received a white coat, a copy of the oath written by their class, and a USF pin. R. Neil White (Class of 2006) received the inaugural Student Professionalism award which is given to a second-year student whose classmates believe most exemplifies the values of professionalism. Representatives from hospitals and centers in the greater Tampa Bay area that served as founding community clinical education centers were also recognized.

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Arts and Crafts Show Dec. 10 and HSC Holiday Party Dec. 17

The annual HSC Arts and Crafts Show will be from 9 a.m. to 3 p.m. Dec. 10 in the HSC breezeway between the USF Medical Clinic and the HSC Human Resources. Lots of great gift ideas: gift baskets, ornaments, stained glass, jewelry, wood crafts and baked goods. New this year is lunch by Travieso Catering: For $6.40, you'll get a choice of baked chicken, roasted pork or shredded beef, served with yellow rice, red or black beans, and plantains. Sold separately will be empanadas, stuffed potatoes and drinks.

There will be mingling and jingling again at this year's HSC Holiday Party. The event is from noon to 2 p.m. Dec. 17 in the courtyard next to the College of Nursing. Tasty food and bagpipers will be there. So should you!

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Mark your calendars for Mini-Med School

The USF Health Sciences Center is sponsoring Mini-Med School Jan. 31 and Feb. 7 from 6:30 to 9 p.m. in the Louise Lykes Ferguson Hall at the Tampa Bay Performing Arts Center. Mini-Med School is a free community outreach program where USF professors, researchers and clinicians tell of the latest medical advances and the future of medicine. Speakers include faculty of the USF colleges of medicine, nursing, public health and school of physical therapy.  

Admission in free! Topics are coming soon! Call (813) 974-3300 for more information

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