Dave Morgan, Ph.D.

Professor
Department of Pharmacology & Therapeutics
Joint Appointment, Dept of Gerontology
Associate Director USF Institute on Aging
Coordinator, Alzheimer Research Laboratory
College of Medicine
University of South Florida
12901 Bruce B. Downs Blvd., MDC Box 9
Tampa, FL 33612-4799
Office : (813) 974-3949
FAX    : (813) 974-2565
E-mail:dmorgan@hsc.usf.edu

Please visit my laboratory homepage for more detailed information.

Dr. Morgan's TV Interviews

Lan/Cable/DSL Version           56KBPS Version

1. ABC Interview                        1. ABC Interview
2. NBC Interview                        2. NBC Interview
3. FOX Interview                        3. FOX Interview


Education


 Research Interests



Publications

Refereed journal articles:

Articles written in 2002

Dave Morgan, R. Kennedy Keller. (2002) What evidence would prove the amyloid hypothesis? Towards rational drug treatments for Alzheimer’s disease. Journal of Alzheimer’s Disease 4 (2002) 257–260.

Paul T. Jantzen, Karen E. Connor, Giovanni DiCarlo, Gary L. Wenk, John L. Wallace, Amyn M. Rojiani, Domenico Coppola, Dave Morgan, and Marcia N. Gordon. (2002) Microglial Activation and ß-Amyloid Deposit Reduction Caused by a Nitric Oxide-Releasing Nonsteroidal Anti-Inflammatory Drug in Amyloid Precursor Protein Plus Presenilin-1 Transgenic Mice. The Journal of Neuroscience, March 15, 2002, 22(6):2246–2254 [Download PDF File]

Marcia N. Gordon, Leigh A. Holcomb, Paul T. Jantzen, Giovanni DiCarlo, Donna Wilcock, Kristal W. Boyett, karen Connor, Jason, Melachrino, James P. O' Callaghan, and Dave Morgan. (2002) Time Course of the Development of Alzheimer-like Pathology in the Doubly Transgenic PS1 + APP Mouse. Experimental Neurology 173, 183–195 (2002) [Download PDF File]

Articles written in 2001

DONNA M. WILCOCK, MARCIA N. GORDON, KENNETH E. UGEN, PAUL E. GOTTSCHALL, GIOVANNI DICARLO, CHAD DICKEY, KRISTAL W. BOYETT, PAUL T. JANTZEN, KAREN E. CONNOR, JASON MELACHRINO, JOHN HARDY, and DAVID MORGAN. (2001) Number of Aß Inoculations in APP1PS1 Transgenic Mice Influences Antibody Titers, Microglial Activation, and
Congophilic Plaque Levels. DNA AND CELL BIOLOGY Volume 20, Number 11, 2001, Mary Ann Liebert, Inc. Pp. 731–736. [Download PDF file]

Dr. Kenneth E. Ugen, Dr. Dave Morgan. (2001) Alzheimer’s Disease: Molecularly Based Immunotherapeutics. DNA AND CELL BIOLOGY Volume 20, Number 11, 2001 Mary Ann Liebert, Inc. Pp. 677–678. [Download PDF file]

Lars N. G. Nilsson, Kelly R. Bales, Giovanni DiCarlo, Marcia N. Gordon, Dave Morgan, Steven M. Paul, and Huntington Potter (2000) à -1-Antichymotrypsin Promotes ß-Sheet Amyloid Plaque Deposition in a Transgenic Mouse Model of Alzheimer’s Disease. The Journal of Neuroscience, March 1, 2001, 21(5):1444–1451. [Download PDF file]

Marcia N. Gordon, David L. King , David M. Diamond, Paul T. Jantzen, Kristal V. Boyett, Caroline E. Hope, Jaime M. Hatcher , Giovanni DiCarlo, W. Paul E. Gottschall, Dave Morgan,  Gary W. Arendash. (2001) Correlation between cognitive deficits and Aß deposits in transgenic APP1PS1 mice. Neurobiology of Aging 22 (2001) 377–386. [Download PDF file]

Dave Morgan, David M. Diamond, Paul E. Gotschall, Kenneth E. Ugens, Chad Dickey, John Hardy, Karen Duff, Paul Jantzen, Giovanni DiCarlo, Donna Wilcock, Karen Connor, Jaime Hatcher, Caroline Hope, Marcia Gordon & Gary W. Arendash (Dec. 2000) Aß Peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. NATURE | VOL 408 | 21/28 DECEMBER 2000. [Download PDF file]

CHAD A. DICKEY,1,2 DAVID G. MORGAN,1,2 SAGAR KUDCHODKAR,3 DAVID B. WEINER,3 YUN BAI,4 CHUANHAI CAO,4 MARCIA N. GORDON,1,2 and KENNETH E. UGEN (2001) Duration and Specificity of Humoral Immune Responses in Mice Vaccinated with the Alzheimer’s Disease-Associated ß-Amyloid 1-42 Peptide. DNA AND CELL BIOLOGY Volume 20, Number 11, 2001 Mary Ann Liebert, Inc. Pp. 723–729. [Download PDF file]

Giovanni DiCarlo, Donna Wilcock, Debbi Henderson, Marcia Gordon, Dave Morgan (2001) Intrahippocampal LPS injections reduce Aß load in APP+PS1 transgenic mice Neurobiology of Aging 22 (2001) 1007–1012. [Download PDF file]

GARY W. ARENDASH, MARCIA N. GORDON, DAVID M. DIAMOND, LEIGH ANN AUSTIN, JAIME M. HATCHER, PAUL JANTZEN, GIOVANNI DICARLO, DONNA WILCOCK, and DAVE MORGAN (2001) Behavioral Assessment of Alzheimer’s Transgenic Mice Following Long-Term Ab Vaccination: Task Specificity and Correlations between Ab Deposition and Spatial Memory. DNA AND CELL BIOLOGY Volume 20, Number 11, 2001 Mary Ann Liebert, Inc. Pp. 737–744 [Download PDF file]

Gary W. Arendash , David L. King , Marcia N. Gordon , Dave Morgan, Jaime M. Hatcher , Caroline E. Hope , David M. Diamond (2001) Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes. Brain Research 891 (2001) 42–53 [Download PDF file]

Articles written in 2000 and before

Holcomb, L.A., M.N. Gordon, S.A. Benkovic and D.G. Morgan (2000). Aß and perlecan in rat brain. Glial activation, gradual clearance and limited neurotoxicity. Mech. Ageing and Develop., 112:135-152.

Leigh A. Holcomb, Marcia N. Gordon, Stanley A. Benkovic, David G. Morgan (1999). Aß and perlecan in rat brain: glial activation,
gradual clearance and limited neurotoxicity. Mechanisms of Ageing and Development 112 (2000) 135–152. [Download PDF file]

Holcomb, L.A., M.N. Gordon, P. Jantzen, K. Hsiao, K. Duff and D. Morgan (1999). Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: Lack of association with amyloid deposits Behavior Genetics, 29:177-185.

Holcomb, L.A., M.N. Gordon, E. McGowan, S. Benkovic, P. Jantzen, K. Wright, I. Saad, R. Mueller, D. Morgan, X. Yu, S. Sanders, C. Zehr, K. O'Campo, J. Hardy, C-M. Prada, C. Eckman, S. Younkin, K. Hsiao, K. Duff. (1998) Accelerated Alzheimer-phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nature Medicine 4:97-101.

Morgan, D., L. Holcomb, I. Saad, M. Gordon and M. Maines (1998). Impaired spatial navigation learning in transgenic mice over-expressing heme oxygenase-1. Brain Research, 808:110-112.

Gordon, M. N., King, D. L., Diamond, D. M., Jantzen, P. T., Boyett, K. L., Hope, C. E., Hatcher, J. M., DiCarlo, G., Gottschall, P., Morgan, D. & Arendash, G. W. (2000). Correlation between cognitive deficits and A_ deposits in transgenic APP+PS1 mice. Neurobiology of Aging, in press

Morgan, D.G. and A. Routtenberg (1981) Brain pyruvate dehydrogenase phosphorylation and enzyme activity altered by a training experience. Science, 214: 470-471.


Manuscripts associated with the submission by Loring et al

Scott Eastman, P. and Jeanne F. Loring. Designing Microarray Experiments for Neurobiology