The College of Medicine, one of the three colleges of the University of South Florida Health Sciences Center, admitted the first class of medical students in 1971. The program and curriculum has expanded from the MD degree to include a MD/PhD program in medical sciences, MD/MPH, MD/MBA, and MD/JD degrees, residency programs in various specialties and sub-specialties, and numerous special fellowship programs of both clinical and scientific specialized training.

The College of Medicine is an academic community of scientific and educational excellence with leadership in medicine, medically related research, and highly specialized medical care services. The faculty is dedicated to programs of education, research, and patient care, while providing its students with educational experiences of the highest quality. The Health Sciences Center and the college have strong ties with other university programs and certain programs have achieved national and international recognition. Relationships with other Health Sciences Center colleges, teaching hospitals, the H. Lee Moffitt Cancer Center and Research Institute, and other disciplines within the university provide a very strong academic and research base. The college is fully accredited by the Liaison Committee on Medical Education for the maximum period.

The College provides educational experiences that begin with pre-professional counseling, includes the program leading to the M.D. degree, residency training, and includes continuing medical education for the practicing physician. Each phase of this educational program has a particular emphasis and significance. In addition, the College of Medicine offers a graduate program leading to a Ph.D. in Medical Sciences and a program in Physical Therapy through its School of Physical Therapy.