Todd S. Wills, MD

Biographical Sketch

Areas of Expertise

Current Research

Hillsborough County Health Department – Clinical Research Unit: 2001 – 2008

Ongoing Protocols (Principal Investigator):

A Multicenter Randomized, Double-Blind, Controlled Study of NGX-4010 for the Treatment of Painful HIV-Associated Neuropathy [NGX-C119]

Evaluating the Diagnostic Performance of an HIV Assay to detect antibodies in Urine Specimens (investigator initiated)

A Phase III randomized, double-blinded, placebo-controlled trial to investigate the efficacy, tolerability and safety of TMC125 as part of an ART including TMC114/RTV and an investigator-selected OBR in HIV-1 infected subjects with limited to no treatment options. [TMC125-C206]

A Phase 2, Randomized Study of the Treatment of Antiretroviral Treatment-Experienced, HIV-1 Infected Subjects Comparing Ritonavir-Boosted GS-9137 (GS-9137/r) Versus a Comparator Ritonavir-Boosted Protease Inhibitor (CPI/r) in Combination with a Background Antiretroviral Therapy” [GS-US-183-0105]

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of a Novel CCR5 Antagonist, UK-427,857, in Combination with Optimized Background Therapy Versus Optimized Background Therapy Along for the Treatment of Antiretroviral-Experienced HIV-1 Infected Subjects. [Pfizer A4001027]

An open-label trial with TMC125 as part of an ART including TMC114/rtv and an investigator-selected OBR in HIV-1 infected subjects who participated in a DUET trial (TMC125-C206 or TMC125-C216). [TMC125-C217]

Ongoing Protocols (Co-Investigator)

A randomized, controlled, partially blinded Phase IIb dose-finding trial of TMC125, in HIV-1 infected subjects with documented genotypic evidence of resistance to currently available NNRTIs and with at least three primary PI mutations [ TMC125-C223]

A Phase II, Randomized, Blinded, 12-Week Comparison of Elvucitabine in Combination with Efavirenz and Tenofovir versus Lamivudine in Combination with Efavirenz and Tenofovir in HIV-1 Infected, Treatment-Naïve Subjects, with a 12-Week Extension Treatment Period [ACH443-015]

A Large, Simple Trial Comparing Two Strategies for Management of Anti-Retroviral Therapy. [SMART CPCRA 065]

A randomized, controlled, open-label trial to compare the efficacy, safety and tolerability of TMC114/ritonavir versus lopinavir/ritonavir in treatment-naïve HIV-1 infected subjects. This trial will be referred to as ARTEMIS. [TMC114-211]

A Phase IIb, Randomized, Partially Blinded, Dose-Finding Trial of TMC278 in Antiretroviral Naïve HIV-1 Infected Subjects [TMC278-204]

An Open-Label Trial with TMC125 in HIV-1 Infected Subjects, Who Were Randomized to a TMC125 Treatment Arm in a Sponsor-Selected TMC125 Trial and were Treated for at least 48 Weeks [TMC125-C229]

A 96-Week, Phase IV, Randomized, Double-Blind, Multicenter Study of the Safety and Efficacy of Epzicom versus Truvada Administered in Combination with Kaletra in Antiretroviral-Naive HIV-1 Infected Subjects” [EPZ104057] –HEAT

A Randomized, Prospective Study of the Efficacy, Safety and Tolerability of Two Doses of GW433908/Ritonavir Given with Abacavir/Lamivudine Fixed Dose Combination. [COL100758]

A Probe Study to Evaluate the Safety, Tolerability, and Immunogenicity of the MRK Adenovirus Serotype 5 Vector (MRKAd5) Human Immunodeficiency Virus Type I (HIV-1) gag Vaccine in HIV-1 Infected Individuals. [Merck V520 – 014]

A Randomized, Controlled, Open-Trial to Compare the Efficacy, Safety and Tolerability of TMC114/RTV versus LPV/RTV in Treatment-Experienced HIV-1 Infected Subjects [TMC114-C214]

Publications

Wills TS, Lopez J, Billington A. Empyema caused by Ralstonia Picketii in a Hemodialysis Patient. Clinical Microbiology Newsletter 29 (7) 55-6. April 2007.

Irvine L, Wills TS. Streptobacillus moniliformis: A mouse trying to become a rat. Clinical Microbiology Newsletter 28 (15) 118-20. August 2006.

Menezes L, Wills TS, D’Souza K. HIV/AIDS Among Asian and Pacific Islander Americans. In Psychiatric Aspects of HIV/AIDS. F. Fernandez, L. Ruiz, ed. Lippencott Williams. 2005.

Irvine L, Wills TS. Sepsis caused by Streptobacillus moniliformis. Clinical Microbiology Newsletter (submitted) June 2005

Toney JF, Wills TS Dermatologic Manifestations of Syphilis. Florida Medical Association Journal. February 2005.

Wills TS, Hepatitis C. Where are we going and where have we been. HemAware. November 2004

Wills TS, Degryse A, Lavina J, Sinnott JT. Blastoschizomyces Capitatus Pneumonia in an Immunocompetent Male. Southern Medical Journal August 2004.

Wills TS, Nadler JP, Somboonwit C. Anemia Prevalence and Associated Risk Factors in a Single-Center Ambulatory HIV Clinical Cohort. AIDS Reader. June 2004

Wills TS, chapter "Gastrointestinal Infections in Cancer Patients" for Infections in Cancer Patients, JN Greene, editor, Marcel Dekker, New York May 2004.

Larkin JA, Lit L, Sinnott JT, Wills TS, and Szentivanyi A. Infection of a Knee Prosthesis with Tsukamurella Species. Southern Medical Journal 92:831, 1999.

ABSTRACTS:

Nadler JP, Wills TS, Somboonwit C, et. al. Anemia prevalence among HIV patients: Anti-retroviral therapy and other risk factors. 2nd International AIDS Society Conference on HIV Pathogenesis and Treatment and the 5th International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV, Paris, France 2003.

Tash K, Wills T, Sinnott J. Rahnella aquatis: A new niche? International Conference of Infectious Diseases. Lisbon, Portugal June 2006.

Pujari S, Wills T, Naik E, Menezes L, et al. Correlates of Anemia for HIV patients in the HAART era: a single center ambulatory clinical cohort in Pune, India. XVI International AIDS Conference – Abstract CD-ROM. Toronto August 2006.

Naik E, D’ Souza BS, Menezes L, Wills T, et. al. A collaboratively designed HIV mini-residency by US and Indian faculty. Association for Medical Education in Europe Conference, Genoa, Italy September 2006.

Menezes L, D’Souza K, Wills T, et al. Capacity-building: Indian physicians benefit from blended curriculum. Association for Medical Education in Europe Conference, Genoa, Italy, September 2006.

D’Souza KR, Menezes L, Wills TS, D’Souza KM. Women infected with HIV and Human Papillomavirus (HPV): an emerging health problem in resource-constrained settings. American Public Health Association (APHA) 134th Annual Meeting and Exposition, Boston, MA, November 2006.

ELECTRONIC PUBLICATIONS:

Wills T, Jaworki MA. Norwalk Virus. eMedicine.com url: http://www.emedicine.com/med/topic1648.htm Updated June 30, 2006.

Wills T, Goodrich JM. Cytomegalovirus. EMedicine.com url: http://www.emedicine.com/MED/topic504.htm Updated August 11,2006

Wills T. Mononucleosis: A Kiss and Tell Story. www.abcnews.com (pending)

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Dr. Will's NIH Biosketch 10-07