John F. Toney, MD, FACP
Biographical Sketch | Areas of Expertise | Current Research | Publications
Biographical Sketch
Dr. John Toney is the Medical Director of the Florida Infectious Diseases Institute at USF College of Medicine, Division of Infectious Disease and International Medicine, and Director of Clinical Infectious Disease Research at the James A. Haley Veterans’ Hospital. His research focuses on clinical STD/HIV therapeutics, investigational anti-infectives, and investigational vaccines. He is a Principal Investigator with the Shingles Prevention Study (VA Cooperative Study CSP#403) herpes zoster vaccine, the largest study ever to investigate this disease and the largest VA vaccine study ever performed (38,546 subjects overall enrolled). This data assisted Merck in receiving FDA approval for the vaccine (Zostavax) in 2006. He is PI with the SPS CSP#403c Long-Term Persistence Substudy, investigating the 10-year overall durability of patients originally vaccinated in the original VA CSP#403 trial. His research is supported by grants from the VA and pharmaceutical company contracts.
He is the founding and current Medical Director of the Southeast Region STD/HIV Prevention Training Center, one of the CDC National Network of STD/HIV Prevention Training Centers. The Southeast Region STD/HIV Prevention Training Center (SEPTC - formerly the Florida STD/HIV PTC) is a joint project of the Florida Department of Health Bureau of STD Prevention and Control (BSTDPC), USF College of Medicine Division of Infectious Disease and International Medicine, and the CDC. The Center was created in 1988 in response to Florida's significant STD morbidity with initial CDC funding until 1992. The Center became a Florida state-funded BSTDPC collaboration effort in 1992 and, at that time, was the only state-supported STD/HIV PTC in the nation. In May 2000, the Center was successful competed for CDC grant funding to become part of the CDC National Network of STD/HIV Prevention Training Centers, and was refunded again by the CDC after competitive grant submission in April 2006 (R30 Cooperative Agreement). SEPTC offers educational training for Florida and other regional healthcare providers in the diagnosis and management of STDs including HIV. SEPTC has provided experiential and educational experiences for over 14,000 participants, including clinical practitioners and allied health care personnel.
Areas of Expertise
Current Research
Principal Investigator / Grant Recipient
State/Federal Grants:
1. Toney JF, Schmitt K. Sexually Transmitted Diseases/Human Immunodeficiency Virus Prevention Training Centers (Funding Opportunity Number: PS06-606) Centers for Disease Control and Prevention (CDC), 2006.
2. Toney JF, Schmitt K, Montero J, Wroten J, Sinnott JT. Sexually Transmitted Diseases/Human Immunodeficiency Virus Prevention Training Centers [Program Announcement 00031]. Centers for Disease Control and Prevention.
3. Toney JF. Sexually Transmitted Diseases (STD) Prevention Training Center of Florida. Florida Dept. of Health and Rehabilitation Services (HRS).
4. Toney JF. VA Cooperative grant CSP #403 Shingles Prevention Study (SPS). (Selected site for SPS Persistance Substudy of CSP#403 – began Aug 2004 - present)
5. Toney JF, Bergen GA. Ryan White Title I Grant - Primary Care for HIV-Infected Patients. Florida Department of Health and Rehabilitative Services (HRS), 1994. Grant #: 94-1336, renewed, 1995.
Pharmaceutical Grants - Principal Investigator:
1. Toney JF, Gompf SG, Oehler RA. Intravenouus Telavancin for Complicated Skin and Soft Tissue Infections. Theravance. 2004 – 2006. (85% effort)
2. Toney JF, Gompf SG, Oehler RA, Cutolo EP, Lazama J. Intravenouus ARBELIC (AMI-6424) for Uncomplicated Staphylococcus aureus Bacteremia (Phase II Study). Theravance. 2003 – present. (85% effort)
Publications
Book Chapters (Refereed)
1. Toney JF. Nongonococcal Urethritis. In: Rakel and Bope eds. Conn's Current Therapy 2005, Elsevier Saunders, Pennsylvania, 2005, pp 857-858.
2. Toney JF. Sexually Transmitted Diseases. In: Baddour and Gorbach eds. Therapy of Infectious Diseases, Elsevier, New York, 2002, pp 469-491.
3. Toney JF, Bergen GA. Sexually Transmitted Diseases. In: Steinhart, Orrick, and Simpson eds. HIV/AIDS Primary Care Guide, University of Florida Press, Florida, 359, 2002.
4. Bergen GA, Toney JF. Colonization versus Infection in the Critical Care Unit. In: Cunha ed. Infectious Diseases in Critical Care Medicine, Marcel Dekker, Inc., New York, 17, 1998.
Articles, Senior Author (Refereed)
1. Toney JF and Diaz J . Syphilis and Pregnancy. Submitted Journal of the Florida Medical Association 2006.
2. Toney JF. Skin manifestations of herpesvirus infections. Current Infectious Disease Reports, 7:359, 2005.
3. Toney JF. Syphilis serology. Journal of the Florida Medical Association, 89:8, 2005.
4. Toney JF. Syphilis - Dermatologic manifestations. Journal of the Florida Medical Association, 89:16, 2005.
5. Toney JF, Bergen GA. Syphilis Elimination -Deja Vu? Infections in Medicine, 17:619, 2000
6. Toney JF, Montero J. Sexually Transmitted Diseases – Where Do We Go From Here? Infections in Medicine 17:92, 2000.
7. Toney JF, Parker MM. New Perspectives on the Management of Septic Shock in the Cancer Patient. Infectious Diseases Clinics of North America 10:239, 1996.
8. Toney JF, Greene JN, Chmel H. Sepsis in the 1990's - The Treatment of Chaos. Cancer Control, 1:539, 1994.
Refereed Articles, Other Senior Author
1. Michael N. Oxman, MD, Myron J. Levin, MD, Gary R. Johnson, MS, Kenneth E. Schmader, MD, Stephen E. Straus, MD, Lawrence D. Gelb, MD, Robert D. Arbeit, MD, Michael S. Simberkoff, MD, Toney JF, et. al. Varicella–Zoster Vaccine to Prevent Herpes Zoster and Postherpetic Neuralgia in Older Adults. New England Journal of Medicine 352:2271, 2005.
2. Carter WW, Gompf SG, Toney JF, Greene JN, Cutolo EP. Disseminated Acanthamoeba Sinusitis in a Patient With AIDS: A Possible Role for Early Antiretroviral Therapy. AIDS Reader 14:41, 2004.
3. Bittner MJ, Toney JF, Eleftheriou PD, Ribner BS. Randomized, double-blind comparison of oral cefpodoxime and parenteral ceftriaxone in hospitalized adults with community-acquired pneumonia. Journal of Clinical Outcomes Management 6:38, 1999.
4. Bergen GA, Toney JF. Colonization versus Infection in the ICU. Critical Care Clinics of North America 14:71, 1998.
5. Larkin JA, Lit L, Toney JF. Syphilis in pregnancy. Infections in Medicine, 15:199, 1998 (also electronically published in Medscape Women's Health 3, 1998)
6. Bone RC, Balk RA, Fein AM, Perl TM, Wenzel RP, Reines HD, Quenzer RW, Iberti TJ, Macintyre N, Schein RMH, E5 Sepsis Study Group (Toney, JF). A Second Large Controlled Clinical Study of E5, a Monoclonal Antibody to Endotoxin: Results of a Prospective, Multicenter, Randomized Controlled Trial. Critical Care Medicine, 23:994, 1995.
Dr. Toney's NIH Biosketch 10-07
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