Division of Infectious Disease & International Medicine
College of Medicine - Department of Internal Medicine

Frederick Heinzel, MD

Associate Professor of Medicine, Division of Infectious Disease & International Medicine

Biographical Sketch | Areas of Expertise | Current Research | Publications
Education
Fellowship, Infectious Disease, University of Washington, Seattle, WA
Internship and Residency, Internal Medicine, University of Washington Affiliated Hospitals, Seattle, WA
MD, University of California, Irvine
BS, Biochemistry, University of California, Davis

Contact Information
Email: Frederick.heinzel@va.gov
Phone: (813) 972-2000 ext. 1748
FAX: (813) 978-5983

Biographical Sketch

Frederick Heinzel, MD is an Infectious Diseases specialist and immunologist with over 50 peer-reviewed publications related to basic and clinical studies of leishmaniasis, T-cell differentiation and the immunobiology of infection and trauma. He provides in-depth knowledge of the basic management, epidemiology and pathophysiology of parasitic and bacterial infections of global importance. 
 
Dr. Heinzel was trained at the University of Washington in Infectious Diseases and was on faculty at the University of California, San Francisco and Case Western Reserve University before joining the Division of Infectious Diseases and International Medicine at University of South Florida.

Areas of Expertise

  • Human leishmaniasis
  • Leprosy
  • Trypanosomiasis

Current Research

2003, VA Merit Review Award, "Immunotherapy of chronic infection." (4/01/03-3/31/06) 
 
2003, Frederick Heinzel (PI), NIH Training Grant T32-AI07024-26 “Training in Geographic Medicine and Infectious Diseases”. (9/1/03 - 8/31/08)

Publications

Johnson AC, Heinzel FP, Diaconu E, Sun Y, Hise AG, Golenbock D, Lass JH and Pearlman E. 2005. Activation of toll-like receptor (TLR)2, TLR4 and TLR9 in the mammalian cornea induces MyD88-dependent corneal inflammation. IOVS. 46:589-95
 
Yadavalli GK, Chien JW, Wener KM, DeVecchio JL, Gupta S, Salata RA, Lee JH, Caldeira C, Auletta JJ and Heinzel FP.  2005. IL-12 and interferon-gamma synthetic deficiency is associated with dendritic cell cytopenia after cardiac surgery. Shock. 24:26-33

Das L, DeVecchio JL and Heinzel FP. 2005. Flt3L-based immunoprophylaxis against infection is improved by adjuvant treatment with anti-IL-10 antibody. J of Infect Dis. 192:693-702.

Greene JA, DeVecchio JL, Gould MP, Auletta JJ and Heinzel FP. 2006. In vivo and in vitro regulation of type I IFN synthesis by synergistic effects of CD40 and Type II IFN. J. Immunol. 176:5995-6003

Gupta S, Gould MP, Devecchio J, Canaday DH, Auletta JJ and Heinzel FP. 2006. CpG-Induced IFN expands TLR4-specific IL-18 responses in vivo. Cell. Immunol. 243:75-82

Daehnel K, Gillette-Ferguson I, Hise AG, Diaconu E, Harling MJ, Heinzel FP and Pearlman E. 2007. Filaria/Wolbachia activation of dendritic cells and development of Th1-associated responses is dependent on Toll-like receptor 2 in a mouse model of ocular onchocerciasis (river blindness). Parasite Immunol. 29:455-65.