Allergy and Immunology

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Current Clinical Research Unit Studies

The Clinical Research Unit has experience in phase II, III and IV, adult and pediatric clinical trials. The Division’s Clinical Research Unit provides quality research in a variety of clinical areas. Our current studies include the following:

  • allergen immunotherapy
  • allergic rhinitis
  • COPD
  • asthma- adult and pediatric
  • chronic urticaria
  • bronchitis
  • exercise induced asthma
  • hereditary angioedema
  • nasal polyps

The funds generated from such studies are used to support our 3-year research and training program in Allergy and Clinical Immunology.

Clinical Expertise
Clinical Procedures
Laboratory Capabilities
  • Allergic rhinitis
  • Allergen immunotherapy
  • Angioedema, acute and chronic
  • Asthma
  • Atopic eczema
  • Bronchitis, acute and chronic
  • Contact dermatitis
  • COPD
  • Exercise-induced asthma
  • Hereditary angioedema
  • Headaches (migraine and tension)
  • Immunodeficiency
  • Insect allergy
  • Nasal polyps
  • Non-allergic rhinitis
  • Osteoporosis
  • Sinusitis, acute and chronic
  • Temporomandibular joint syndrome
  • Urticaria, acute and chronic
  • Acoustic rhinometry
  • Allergen challenge (lung)
  • Allergen challenge (nasal, using acoustic rhinometry)
  • Allergy skin test
  • Asthma control test
  • Blood draw
  • ECG
  • End-point skin titration
  • Exercise challenge
  • Exhaled nitric oxide
  • Hypertonic saline challenge
  • Impedance oscillometry
  • Mannitol challenge
  • Methacholine challenge
  • Microscopy
  • Nasal scraping
  • Nasal secretion collection
  • Pollen counts
  • Rhinoscopy
  • Rhinomanometry
  • Spirometry with pre- and post- bronchodilation
  • Sputum induction
  • Study drug infusion
  • Urine drug screen
  • Urine hCG
  • Flow cytometry
    • Cell surface phenotyping of peripheral blood mononuclear cells (PBMC), up to 14 parameters (BD FACS Canto II)
    • Intracellular cytokine staining of PBMC
    • Apoptosis/cell cycle assays
    • Functional analysis of lymphocyte populations
    • Magnetic (Miltenyi Automacs Pro) or flow cytometric (BD FACS Aria II) sorting of lymphocyte subsets
  • Antigen-specific and nonspecific lymphocyte proliferation/differentiation
  • Chemokine/cytokine assays
  • Cytometric bead arrays for cytokines/ chemokines
  • Real-time quantitative PCR
    • Analysis of PBMC cytokine/ chemokine mRNA expression (individual cytokines genes or PCR arrays)
    • Identification and quantification of plasma miRNA (proprietary TaqMan assay)
    • Detection of serum / body fluid cytokine and chemokine levels
    • Detection of serum antibody subtypes
  • Biomarker assessment

* Studies are usually looking for participants ages 6 years and older for asthma and allergy trials and 40 years and older for COPD trials. For more information please call the Clinical Research Unit at 813-631-4024.