 |
Jie
Wu, Ph.D. Member-in-Residence of the Moffitt Cancer Center E-mail: Jerry.Wu@moffitt.org |
Training
B.S.:
Xiamen University, Xiamen, China, 1982.
Ph.D.: University of Kansas Medical Center, Kansas City, Kansas, 1988.
Postdoctoral Fellow: Memorial Sloan-Kettering Cancer Center, New York,
New York.
Postdoctoral Fellow: University of Virginia, Charlottesville, Virginia.
Research
Interests
The long-term goals of my laboratory are to reveal the signal transduction mechanisms that control cell proliferation, differentiation, survival, and motility and to explore key signaling molecules as targets for cancer therapy. We are interested in understanding fundamental cell signaling mechanisms that regulate cellular responses to extracellular cues as well as abnormal signal transduction pathways that mediate malignant growth and metastasis. Our research areas include ErbB, Src, and Bcr-Abl tyrosine kinases, Gab family docking proteins, SHP1 and SHP2 tyrosine phosphatases, MAP kinases, lysophosphatidic acid, and molecular chaperones. We are particularly interested in breast cancer, prostate cancer, and leukemia. Multidisciplinary approaches of molecular biology, biochemistry, cell biology, immunology, and bioinformatics are routinely used in our studies.
Search
for publications by: 
This
search will be conducted at the US National Library of Medicine (NLM) and PubMed.
Selected Publications
Ren, Y, Meng, S., Mei, L., Zhao, J., Jove, R. and Wu, J. (2004) Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor. J. Biol. Chem. 279, 8497-8505.
Fragale, A., Tartaglia, M., Wu, J., and Gelb, B. D. (2004) Noonan syndrome-associated SHP2/PTPN11 mutants cause EGF-dependent prolonged Gab1 binding and sustained Erk2/MAPK1 activation. Human Mutat. 23, 267-277.
Sun, Y., Yuan, J., Liu, H., Shi, Z., Baker, K., Vuori, K., Wu, J., and Feng, G. S. (2004) Role of Gab1 in UV-induced c-Jun NH2-terminal kinase activation and cell apoptosis. Mol. Cell. Biol. 24, 1531-1539.
Guo, F., Sigua, C., Bali, P., George, P., Fiskus, W., Scuto, A., Annavarapu, S., Mouttaki, A., Sondarva, G., Wei, S., Wu, J., Djeu, J., and Bhalla, K. (2004) Mechanistic role of heat shock protein 70 in Bcr-Abl mediated resistance to apoptosis in human acute leukemia cells. Blood. 2004 Sep 23 [Epub ahead of print]
Kong, X., San Juan, H., Behera, A., Peeples, M. E., Wu, J., Lockey, R. F., and Mohapatra, S. S. (2004) ERK-1/2 activity is required for efficient RSV infection. FEBS Lett. 559, 33-38.
Ren, Y. and Wu, J. (2003) Simultaneous suppression of Erk and Akt/PKB activation by a Gab1 pleckstrin homology (PH) domain decoy. Anticancer Res. 23, 3231-3236.
Nimmanapalli, R., Bali, P., O'Bryan, E., Fuino, L., Guo, F., Wu, J., Houghton, P. and Bhalla, K. (2003) Arsenic trioxide inhibits translation of mRNA of bcr-abl, resulting in attenuation of Bcr-Abl levels and apoptosis of human leukemia cells. Cancer Res. 63, 7950-7958.
Nimmanapalli, R., Fuino, L., Bali, P., Gasparetto, M., Glozak, M., Tao, J., Moscinski, L., Smith, C., Wu, J., Jove, R., Atadja, P., and Bhalla, K. (2003) Histone deacetylase inhibitor LAQ824 both lowers expression and promotes proteasomal degradation of Bcr-Abl and induces apoptosis of imatinib mesylate-sensitive or -refractory chronic myelogenous leukemia-blast crisis cells. Cancer Res. 63, 5126-5135.
Dorsey, J. F., Cunnick, J. M., Mane, S. M. and Wu, J. (2002) Regulation of the Erk2-Elk1 signaling pathway and megakaryocytic differentiation of the Bcr-Abl + K562 cells by Gab2. Blood 99, 1388-1397.
Cunnick, J. M., Meng, S., Ren, Y., Desponts, C., Wang, H., Djeu, J., and Wu, J. (2002) Regulation of the mitogen-activated protein kinase signaling pathway by SHP2. J. Biol. Chem. 277, 9498-9504.
Dorsey, J. F., Cunnick, J. M., Lanehart, R., Bhalla, K., Kraker, A. J. Jove, R., and Wu, J. (2002) Interleukin-3 protects Bcr-Abl-transformed hematopoietic progenitor cells from apoptosis induced by Bcr-Abl tyrosine kinase inhibitors. Leukemia 16, 1589-1595.
Yang, J., Kim, O., Wu, J., and Qiu, Y. (2002) Interaction between tyrosine kinase Etk and a RUN-domain and FYVE-domain containing protein RUFY1: A possible role of Etk in regulation of endocytosis. J. Biol. Chem. 277, 30219-30226.
Huang, M., Dorsey, J. F., Epling-Burnette, P. K., Nimmanapalli, R., Landowski, T., Mora, L., Niu, G., Sinibaldi, D., Bai, F., Kraker, A., Yu, H., Moscinski, L., Wei, S., Djeu, J., Dalton, W., Bhalla, K., Loughran, T. P., Wu, J., and Jove, R. (2002) Inhibition of Bcr-Abl kinase activity by PD180970 blocks constitutive activation of Stat5 and growth of chronic myeloid leukemic cells. Oncogene 21, 8804-8816.
Kim, S-O., Loesch, K., Wang, X., Jiang, J., Mei, L., Cunnick, J., Wu, J., and Frank, S. J. (2002) A role for Grb2-associated binder (Gab)-1 in growth hormone signaling. Endocrinology 143, 4856-4867.
Cancer Biology Ph.D. Program
H. Lee Moffitt Cancer Center, MRC-4 East
12902 Magnolia Drive
Tampa, Florida 33612
Phone: 813-745-6876
E-mail: CancerPHD@moffitt.org
Copyright © 2000 University of South Florida