Hong-Gang Wang, Ph.D. Associate Professor in the Interdisciplinary Oncology Program Member-in-Residence of the Moffitt Cancer Center E-mail: Hong-Gang.Wang@moffitt.org Phone: (813) 745-6764

Training
B.Sc.: University of Tsukuba, Japan, 1987.
Ph.D.: University of Tsukuba, Japan, 1992.
Postdoctoral Fellow: The Burnham Institute, La Jolla, CA, 1993-1998.

Research Interests

Much of the work in our laboratory is concerned with understanding of the mechanisms that control programmed cell death and cell cycle checkpoints in the context of oncogenesis.  In addition, development of small molecules that directly target the core components of the cell death machinery for drug discovery is also one of the major research interests of our laboratory.

Search for publications by:   
This search will be conducted at the US National Library of Medicine (NLM) and PubMed.

Selected Publications:

Yamaguchi H and Wang H-G: Tissue transglutaminase serves as an inhibitor of apoptosis by cross-linking caspase-3 in thapsigargin-treated cells. Mol. Cell. Biol. 26: 569-579, 2006.

Takahashi Y, Karbowski M, Yamaguchi H, Kazi A, Wu J, Sebti SM, Youle RJ, and Wang H-G: Loss of bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis. Mol. Cell. Biol. 25: 9369-9382, 2005.

Hirai H and Wang H-G: A role of the C-terminal region of human Rad9 (hRad9) in nuclear transport of the hRad9 checkpoint complex. J. Biol. Chem. 277: 25722-25727, 2002.

Komatsu K, Miyashita T, Hang H, Hopkins KM, Zheng W, Cuddeback S, Yamada M, Lieberman HB, Wang H-G: Human homologue of S. pombe Rad9 interacts with BCL-2/BCL-x_L and promotes apoptosis. Nat. Cell Biol. 2(1): 1-6, 2000.

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Cancer Biology Ph.D. Program
H. Lee Moffitt Cancer Center, MRC-4 East
12902 Magnolia Drive
Tampa, Florida 33612
Phone: 813-745-6876
E-mail: CancerPHD@moffitt.org
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