Jessica L. Moore, Ph.D.
Assistant Professor, Biology, Division of Cell Biology,
Microbiology and Molecular Biology, USF
Member of the Moffitt Cancer Center & Research Institute
E-mail:jmoore@cas.usf.edu
Phone: (813)974-3263
Training
Instructor - Jake Gittlen Cancer Research Institute 2001-2004
Senior Postdoctoral Fellow - Jake Gittlen Cancer
Research Institute 1995-2001
Postdoctoral Fellow - Waksman Institute, Rutgers 1994-1995
Ph.D.- University of Texas at Austin 1994
Research
Interests
The modern theory of cancer is that it begins with changes to common cellular components resulting in the accumulation of mutations that lead to the overproliferation and inappropriate growth known as a tumor. Research in my lab is currently focused on two main areas of cancer genetics using the small freshwater zebrafish, Danio rerio, as a model organism for human cancer. One project underway is to map and characterize several novel mutations in zebrafish that cause genomic instability, the gin mutations (Moore et al., 2006). The effects of these mutations can be studied from the early embryonic stages of development to the formation of tumors in adult zebrafish. Adults that carry only one mutant copy of the genomic instability genes seem to have a dramatically increased susceptibility to cancer by developing a variety of tumors, with similar pathology to that seen in humans! A second area of research uses zebrafish as a model system for testicular cancer. Abnormal testicular masses are extremely frequent in zebrafish males. We are looking at patterns of differential gene expression and oncogene activity in zebrafish testicular cancer to better understand human testicular cancer.
Search
for publications by: 
This
search will be conducted at the US National Library of Medicine (NLM) and PubMed.
Selected Publications
Moore, J.L., Rush, L.R., Breneman, C., Mohideen, M.P.K.and Cheng, K.C. (2006) Zebrafish genomic instability mutants and cancer susceptibility. Genetics, October issue, in press, (cover article).
Lamason, R.L., Mohideen, M.A., Mest, J.R., Wong, A.C., Jurynec, M.J., Mao, X., Humphreville, V.R., Humbert, J.E., Sinha, S., Moore, J. L., Jagadeeswaran, P., Zhao, W., Ning, G., Makalowska, I., McKeigue, P.M., O’Donnell, D., Kittles, R., Parra, E.J., Mangini, N.J., Grunwald, D.J., Shriver, M.D., Canfield, V.A., and Cheng, K. C. (2005) SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans. Science, 310: 1782-1786 (cover article).
Moore, J.L., Gestl, E. E. and Cheng, K.C. (2004) Mosaic eyes, genomic instability mutants and cancer susceptibility. In “Zebrafish—Cellular and Developmental Biology”. H. Detrich, M. Westerfield, L. Zon, eds. Methods in Cell Biology, 76: 553-566.
Mohideen, M-A, P.K, Beckwith, L.B., Tsao-Wu, G.S., Moore, J.L., Wong, A.C.C., Chinoy, M.R. and Cheng, K.C. (2003) Histology-based screen for zebrafish mutants with abnormal cell differentiation. Developmental Dynamics, 28: 414-423.
Beckwith, L.G., Moore, J.L., Tsao‑Wu, G.S., Harshbarger, J.C., and Cheng, K.C. (2000) Ethylnitrosourea induces neoplasia in zebrafish (Danio rerio). Laboratory Investigation 80: 379‑385.
Cancer Biology Ph.D. Program
H. Lee Moffitt Cancer Center, MRC-4 East
12902 Magnolia Drive
Tampa, Florida 33612
Phone: 813-745-6876
E-mail: CancerPHD@moffitt.org
Copyright © 2000 University of South Florida