 |
Alvaro
N.A. Monteiro, Ph.D. Member-in-Residence of the Moffitt Cancer Center E-mail:
Alvaro.Monteiro@moffitt.org |
Training
B.S.: Federal University of Rio de Janeiro, Genetics, 1985
Ph.D.: Federal University of Rio de Janeiro, Biochemistry, 1992
Postdoctoral Fellow: The Rockefeller University, 1994-1998
Research
Interests
The long-range goal of the laboratory is to elucidate the
role of genes involved in the development of breast and ovarian cancer.
Our primary focus is on the function of the tumor suppressor gene BRCA1.
Hereditary breast and ovarian cancer represent ~5% of all cases and inherited
mutations in BRCA1 account for the majority of breast and ovarian cancer
families. The human BRCA1 gene codes for a nuclear phosphoprotein, which
is likely to be multifunctional. Recent genetic and biochemical evidence
points to the involvement of BRCA1 in two fundamental cellular processes:
DNA damage response and transcriptional regulation. The following research
projects stem from our initial observations that BRCA1 is able to regulate
gene expression as well as modulate the action of other transcription
factors such as p53. Our immediate goals are two-fold: a) dissect the
BRCA1 biochemical pathway and determine its precise biochemical function
and; b) develop a functional assay to provide more reliable information
for risk assessment in individuals carrying germline mutations in BRCA1.
Search
for publications by: 
This
search will be conducted at the US National Library of Medicine (NLM) and PubMed.
Selected
Publications
1. Monteiro
ANA, August A and Hanafusa H. (1996) Evidence for a transcriptional activation
function of BRCA 1 C-terminal region. Proc. Natl. Acad. Sci. USA. 93:13595-13599.
2. Monteiro ANA, August A and Hanafusa H. (1997) Common BRCA1 variants and transcription activation. Am. J. Hum. Genet. 61:761-762.
3. Ouchi T, Monteiro ANA, August A and Hanafusa H. (1998) BRCA1 regulates p53-dependent gene expression. Proc. Natl. Acad. Sci. USA 95:2302-2306.
4. Hayes F, Cayanan C, Barilla D, Monteiro ANA (2000) Functional assay for BRCA1: Mutagenesis of C-terminal region reveals critical residues for transcription activation. Cancer Res. 60:2411-2418.
5. Nadeau, G, Boufaied, N, Moisan, A, Lemieux, K, Cayanan, C, Monteiro ANA and Gaudreau L. (2000) BRCA1 can stimulate gene transcription by a unique mechanism. EMBO Reports 1:260-265.
6. Monteiro ANA (2000) BRCA1: exploring the links to transcription Trends Biochem. Sci. 25:469-474.
7. Vallon-Christersson J, Haraldsson K, Bergthorsson JT, Nielsen KB, Gerdes AM, Møller P, Kristoffersson U, Olsson H, Borg Å and Monteiro ANA (2001). Functional analysis of BRCA1 C-terminal missense mutations identified in breast and ovarian cancer families. Human Mol. Genet. 10:353-360.
8. Worley T, Vallon-Christersson J, Billack B, Borg Å and Monteiro ANA (2002) A Temperature-sensitive BRCA1 mutant. Cancer Biology and Therapy 1:497-501.
9. Monteiro ANA (2003) BRCA1: the enigma of tissue-specific tumor development. Trends in Genetics, 19:312-315.
10. Mirkovic
N, Marti-Renom M, Weber BL, Sali A, Monteiro ANA (2004) Structural-based
assessment of missense mutations in human BRCA1: Implications for breast
and ovarian cancer predisposition. Cancer Res. In press.
Cancer Biology Ph.D. Program
H. Lee Moffitt Cancer Center, MRC-4 East
12902 Magnolia Drive
Tampa, Florida 33612
Phone: 813-745-6876
E-mail: CancerPHD@moffitt.org
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