 |
William
Douglas Cress, Jr., Ph.D. E-mail:
Douglas.Cress@moffitt.org |
Training
B.S. Virginia Polytechnic Institute and State University, Biochemistry
(Summa Cum Laude) 1986
Ph.D. Michigan State University, Biochemistry 1991
Postdoc. Fellow, Duke University Medical Center, Lab of Dr. Joseph Nevins
1991-1995
Research
Interests
My laboratory is interested in understanding in the E2F transcription
factor family that is thought to be one of the key regulators of cell
growth and cell death. Presently, the laboratory has two major projects.
In the first project we are using DNA chip (or microarray) technology to identify genes that are regulated by members of the E2F family. Going into this project we knew that E2F1 could activate transcription of several genes and that its expression could drive DNA synthesis and, in higher doses, cell death. Surprisingly, in our microarray experiments we found that E2F-1 expression resulted in the transcriptional repression of numerous promoters. We are further investigating the numerous E2F-regulated promoters that we have identified to determine their roles in controlling cell proliferation and cell death.
A second project revolves around a novel member of the E2F family, E2F3B, which was identified by a graduate student in the lab. Because E2F3B is most abundant in cells that are quiescent, it is our hypothesis that E2F3B has a growth restraining activity. To test this hypothesis, we are using adenovirus vectors to express E2F3B to determine it affect on cell growth control relative to other member of the E2F family.
Search
for publications by: 
This
search will be conducted at the US National Library of Medicine (NLM) and PubMed.
Selected
Publications
Croxton, R. L., Ma, Y., Song. L, Haura, E. B., and Cress, W. D. 2002.
Repression of the Mcl-1 Promoter by E2F-1. Oncogene 21: 1359-1369.
Croxton, R. L., Ma, Y., and Cress, W. D. 2002. Distinct DNA Binding Properties
Specify Repression of the Mcl-1 Promoter by E2F1, but not by E2F4. Oncogene
21: 1563-1570.
Ma, Y., Croxton, R. L., Moorer, Jr. R., and Cress, W. D. 2002. Identification
of Novel E2F Regulated Genes by Microarray. Archive of Biochemistry and
Biophysics 399:212-224
He, Y. and W.D. Cress. 2002. E2F-3B is a Physiological Target of Cyclin
A. J. Biol. Chem. 277:23493-23499.
Cancer Biology Ph.D. Program
H. Lee Moffitt Cancer Center, MRC-4 East
12902 Magnolia Drive
Tampa, Florida 33612
Phone: 813-745-6876
E-mail: CancerPHD@moffitt.org
Copyright © 2000 University of South Florida