Esteban Celis, M.D., Ph.D.
Professor, Department of Interdisciplinary Oncology
Member-in-Residence of the Moffitt Cancer Center
E-mail:Esteban.Celis@moffitt.org
Phone: (813)745-1925
Training
M.D. - National University of Mexico, Mexico City 1976
Postdoctoral Fellow - MIT, Cambrige, MA 1977-1979
Ph.D.- National University of Mexico, Mexico City 1980
Research
Interests
Dr. Celis’ current research pertains to recognition and destruction of tumor cells by T-lymphocytes, and his research interests focus on the development of immune-based therapies for cancer. Four areas of research are being investigated in his laboratory: 1) identification of T-cell epitopes at peptide level from known tumor-associated antigens; 2) overcoming immunological tolerance to self-non-mutated tumor-associated antigens as a way of eliciting strong and effective anti-cancer immunity; 3) regulation of T-cell responses to tumor cells by lymphokines and costimulatory signals; and 4) the role of helper T cells in the regulation for cytotoxic T cell responses to tumor antigens. Dr. Celis has been involved in several clinical trials evaluating therapeutic vaccines for cancer.
Search
for publications by: 
This
search will be conducted at the US National Library of Medicine (NLM) and PubMed.
Selected Publications
1. Kennedy, R., A. H. Undale, W. C. Kieper, M. S. Block, L. R. Pease, and E. Celis. 2005. Direct cross-priming by th lymphocytes generates memory cytotoxic T cell responses. J Immunol 174:3967.
2. Undale, A. H., P. J. van den Elsen, and E. Celis. 2004. Antigen-independent acquisition of MHC class II molecules by human T lymphocytes. Int Immunol 16:1523.
3. Lu, J., Y. Higashimoto, E. Appella, and E. Celis. 2004. Multiepitope Trojan antigen peptide vaccines for the induction of antitumor CTL and Th immune responses. J Immunol 172:4575.
4. Kobayashi, H., T. Nagato, M. Yanai, K. Oikawa, K. Sato, S. Kimura, M. Tateno, R. Omiya, and E. Celis. 2004. Recognition of adult T-cell leukemia/lymphoma cells by CD4+ helper T lymphocytes specific for human T-cell leukemia virus type I envelope protein. Clin Cancer Res 10:7053.
5. Davila, E., R. Kennedy, and E. Celis. 2003. Generation of antitumor immunity by cytotoxic T lymphocyte epitope peptide vaccination, CpG-oligodeoxynucleotide adjuvant, and CTLA-4 blockade. Cancer Res 63:3281.
Cancer Biology Ph.D. Program
H. Lee Moffitt Cancer Center, MRC-4 East
12902 Magnolia Drive
Tampa, Florida 33612
Phone: 813-745-6876
E-mail: CancerPHD@moffitt.org
Copyright © 2000 University of South Florida