 |
Wenlong
Bai, Ph.D. E-mail:
wbai@hsc.usf.edu |
Training
Ph.D., University of Texas M. D. Anderson Cancer Center, 1992 Postdoctoral
Fellowship, Baylor College of Medicine at Texas Medical Center, 1992-1997
Research
Interests
Dr. Bai's laboratory focuses on the role of steroid and Vitamin D receptors
in the development and treatment of human cancers. There are three on-going
projects in the lab. 1) Role of the estrogen receptors (ER) in mediating
the agonistic and antagonistic activity of estrogens and antiestrogens
in human cancer cells. This project mainly investigate why tamoxifen,
a SERM (selective estrogen receptor modulator) which is an ER antagonist
widely used for the clinical treatment of ER-positive breast cancers,
acts as an ER agonist to stimulate the development of uterine cancers.
2) Functional interaction between PTEN tumor suppressor and the androgen
receptor in the growth and apoptosis of prostate cancer cells. The project
investigates the novel function of PTEN tumor suppressors in determining
the response of prostate cancers to androgen and androgen ablation therapy.
3) Vitamin D and its receptors in ovarian cancer development and treatment.
This project focuses on the mechanism of Vitamin D action in normal and
malignant ovarian surface epithelial cells and examines the in vitro as
well as in vivo response of ovarian cancer cells to Vitamin D and synthetic
Vitamin D analogs. The overall objectives of the research is, through
the elucidation of the mechanism of action of steroid hormones and Vitamin
D in human cancer cells, to provide molecular basis for either the development
of new therapeutic strategies for cancer patients or the improvement of
the patients' response to exiting anti-hormone therapies.
Search
for publications by: 
This
search will be conducted at the US National Library of Medicine (NLM) and PubMed.
Selected Publications
Yang Y, Hou L, Haller E, Nicosia SV and Bai W. Suppression of FOXO1 Activity by FHL2 through SIRT1-mediated Deacetylation. EMBO J. Reviewed and being revise.
Zhang X, Jiang F, Li P, Li C, Ma Q, Nicosia SV and Bai W. (2004) Suppression of Ovarian Cancer Growth by Synthetic Vitamin D Analog EB1089 in Nude Mice. Clinical Cancer Research . In press.
Feng Jiang, Junying Bao, Pengfei Li, Santo V. Nicosia and Bai W (2004) Induction of Ovarian Cancer Cell Apoptosis by 1,25-dihydroxyvitamin D 3 through the down Regulation of Telomerase. Journal of Biological Chemistry . Epub 2004, Oct 12.
Li P, Li C, Zhao X, Zhang X, Nicosia SV and Bai W. (2004) p27 Kip1 Stabilization and G1 Arrest by 1,25-Dihydroxyvitamin D 3 in Ovarian Cancer Cells Mediated through Down Regulation of Cyclin E/CDK2 Kinase and SCF/Skp2 Ubiquitin Ligase Journal of Biological Chemistry. Jun 11;279(24):25260-7. Epub 2004, Apr 09.
Jiang F, Li P, Fornace AJ Jr, Nicosia SV, Bai W (2003) G2/M Arrest by 1,25 dihydroxyvitamin D3 in Ovarian Cancer Cells Mediated through the Induction of GADD45 via an Exonic Enhancer. Journal of Biological Chemistry. 278:48030-40.
Li P, Lee H, Guo S, Unterman TG, Jenster G and Bai W. (2003) AKT-independent Protection of Prostate Cancer Cell Apoptosis Mediated through Androgen-independent Complex Formation between Androgen Receptor and FKHR. Molecular and Cellular Biology, 23: 104-118.
Lee H and Bai W. (2002) Inhibition of Estrogen Receptor Nuclear Export by Ligand-induced and p38-mediated Receptor Phosphorylation. Molecular and Cellular Biology. 22: 5835-5845.
Li P, Nicosia SV and Bai W. (2001) Antagonism Between PTEN/Mmac1/Tep-1 and Androgen Receptor in Growth and Apoptosis of Prostate Cancer Cells. Journal of Biological Chemistry. 276: 20444-20450.
Lee H, Jiang F, Wang Q, Nicosia SV, Yang J, Su B and Bai W. (2000) MEKK1 Activation of Human Estrogen Receptor and Stimulation of the Agonist Activity of 4-Hydoxytamoxifen in Endometrial and Ovarian Cancer Cells. Molecular Endocrinology. 14: 1882-1896.
Cancer Biology Ph.D. Program
H. Lee Moffitt Cancer Center, MRC-4 East
12902 Magnolia Drive
Tampa, Florida 33612
Phone: 813-745-6876
E-mail: CancerPHD@moffitt.org
Copyright © 2000 University of South Florida